Table 4.
Influence of baseline factors and treatment modification to developed Transmitted Drug Resistance (TDR) and Acquired Drug Resistance (ADR).
| Naive | adjusted | Treated | Adjusted | |||||
|---|---|---|---|---|---|---|---|---|
| Variables | Sig | OR (95% C.I Expected) | Sig | OR (95% C.I Expected) | Sig | OR (95% C.I Expected) | Sig | OR (95% C.I Expected) |
| Gender (Female(a)/Male, n = 1475) | 0.913 | 1.024(0.666–1.576) | 0.148 | 1.332(0.903–1.966) | ||||
| Age (n = 1465) | 0.026 | 1.021(1.0029–1.002) | 0.938 | 1.001(0.985–1.016) | 0.001 | 1.032(1.013–1.053) | 0.003 | 1.043(1.014–1.072) |
| Country (n = 1490) | ||||||||
| Angola (No(a)/Yes) | 0.666 | 1.119(0.671–1.867) | 0.482 | 1.159(0.767–1.752) | ||||
| Brazil (No(a)/Yes) | 0.768 | 0.914(0.505–1.657) | 0.724 | 1.138(0.587–2.208) | ||||
| Cape Verde (No(a)/Yes) | 0,398 | 0.775(0.429–1.401) | 0.162 | 1.389(0.877–2.200) | ||||
| Guinea (No(a)/Yes) | 0.335 | 0.788(0.485–1.280) | 0.025 | 0.591(0.373–0.935) | 0.932 | 1.030(0.521–2.036) | ||
| Mozambique (No(a)/Yes) | 0.005 | 2.319(1.289–4.172) | <0.001 | 2.71(1.605–2.730) | 0.737 | 0.877(0.408–1.886) | ||
| Sao Tome (No(a)/Yes) | 0.594 | 0.754(0.266–2.133) | 0.884 | 0.934(0.374–2.334) | ||||
| Subtype (n = 1490) | ||||||||
| CRF02_AG (No(a)/Yes) | 0.320 | 0.766(0.453–1.290) | 0.007 | 0.521(0.324–0.839) | ||||
| A (No(a)/Yes) | 0.180 | 0.376(0.090–1.570) | 0.670 | 0.825(0.340–2.002) | ||||
| B (No(a)/Yes) | 0.027 | 1.780(1.067–2.969) | 0.022 | 1.719(1.082–2.730) | 0.011 | 2.169(1.191–3.950) | 0.019 | 2.687(1.175–6.143) |
| C (No(a)/Yes) | 0.141 | 1.484(0.877–2.510) | 0.437 | 0.8707(0.470–1.386) | ||||
| D (No(a)/Yes) | 0.599 | 0.580(0.076–4.407) | 0.324 | 2.2183(0.455–10.803) | ||||
| F (No(a)/Yes) | 0.061 | 2.045(0.967–4.323) | 0.254 | 0.525(0.173–1.589) | ||||
| G (No(a)/Yes) | 0.112 | 0.545(0.258–1.151) | 0.168 | 1.407(0.866–2.286) | ||||
| Rec (No(a)/Yes) | 0.377 | 0.752(0.400–1.414) | 0.701 | 1.102(0.670–1-813) | ||||
| CD4 (n = 375) | 0.355 | 1.001(0.999–1.003) | 0.231 | 1.000(0.999–1.003) | ||||
| VL(731) | 0.294 | 0.803(0.532–1.210) | 0.002 | 0.634(0.477–0.842) | 0.001 | 0,600(0.446–0.808) | ||
| Sampling year | 0.003 | 1.085(1.029–1.145) | 0.007 | 1.078(1.021–1.139) | 0.005 | 0.935(0.892–0.979) | 0.001 | 0.821(0.734–0.919) |
Logistic regression of variables at the genotyping collection associates to transmitted and acquired drug resistance. The p values highlighted in bold in the simple analysis were retained for the adjusted analysis