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. 2020 Mar 20;9(3):57. doi: 10.3390/biology9030057

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Expression of specific markers of senescence p16INK4A, p19ARF, p21 and p53. The expression of p16INK4A (a), p19ARF (b), p21 (c) and p53 (d) was evaluated in H₂O₂-senescent hADSCs pre-exposed for 12, 24, or 48 h to ascorbic acid (CTRL+, blue bars) or to Lab by-P (yellow bars) or Ind by-P (red bars). Grey bars represent the hADSCs exposed to H₂O₂, without pre-treatment with the different compounds. The mRNA levels for each gene were expressed as fold of change (2^−∆∆Ct) of mRNA levels observed in untreated hADSCs (CTRL-, black bar) defined as 1 (mean ± SD; n = 6) and normalized to hypoxanthine phosphoribosyltransferase 1 (HPRT1). Data are represented as mean ± SD referring to the control (* p ≤ 0.05).