Figure 3.

Half-lives of (a) mixture A1 (comprised of 1:1 ratio of 10 and 100 kDa toxin fractions) and (b) mixture B1 (comprised of 1:1 ratio of 10 and 60 kDa toxin fractions) calculated from two-compartment pharmacokinetic (PK) parameters of each run in the “likely field case” scenario. On each box, the central red line indicates the median, and the bottom and top edges of the box indicate the 25th and 75th percentiles, respectively. Magenta lines are the nominal half-lives (calculated from the clearance, CL, and volume of distribution, V, of the prior) of toxins based on their molecular weights.