Table A2.

Parameter values for the simulation.

Parameters	Parameter Values
${\mathsf{\sigma }}_{prior,lnCL}$	1.6528
${\mathsf{\sigma }}_{prior,lnV}$	0.7525
${\omega }_{CL}^2$	0.175
${\omega }_V^2$	0.0852
${\mathsf{\sigma }}_{prop}$	0.217
${\mathsf{\sigma }}_{add}$	0.001

Abbreviations: ${\mathsf{\sigma }}_{prior,lnCL}$, prior uncertainty associated with the regression model for clearance; ${\mathsf{\sigma }}_{prior,lnV}$, prior uncertainty associated with the regression model for volume of distribution; ${\omega }_{CL}^2$, between subject variance of clearance; ${\omega }_V^2$, between subject variance of volume of distribution, ${\mathsf{\sigma }}_{prop}$, proportional error; ${\mathsf{\sigma }}_{add}$, additive error.