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. 2020 Mar 17;12(3):325. doi: 10.3390/v12030325

Figure 2.

Figure 2

QuantSeq analysis reveals differential expression patterns of host genes in CVB3-infected hNPCs. hNPCs were infected with CVB3 (MOI 5) and RNA was harvested at 4, 24, 48, and 72 h post infection (hpi). (A) Scatter plot shows the x-axis and y-axis indicating the expression levels of genes from mock-infected and virus-infected groups, respectively. Relatively highly expressed genes in the virus-infected groups (red) and mock-infected groups (green) are depicted. Black dots represent genes that were not classified as differentially expressed. The differentially expressed gene (DEG) count was identified by comparing mock- and virus-infected groups (fold change > 2) (B) Venn diagrams representing the overlap in DEG profiles of CVB3-infected cells. Numbers of upregulated genes (more than 100 folds) are indicated in red and downregulated genes are in blue. (C) Three-dimensional multi-dimensional scaling (3D-MDS) plot of QuantSeq datasets shows that 24, 48, and 72 hpi samples are clustered in locations different from the mock or 4 hpi samples.