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. 2020 Mar 21;12(3):197. doi: 10.3390/toxins12030197

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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αM-MIIIJ (10 μM) blocks neuromuscular transmission in mouse muscle. Extracellular recording of the mouse levator auris longus (LAL) muscle’s action potential evoked by indirect stimulation was performed as described in Methods. Plot of peak (negative) amplitude of muscle action potential as a function of time before, during exposure to 10 μM αM-MIIIJ (indicated by black bar), and after toxin washout. Inset shows example traces of the extracellularly-recorded action potential before (trace 1), during block by toxin (trace 2) and after washout (trace 3), with trace numbers corresponding to times indicated in the main plot. The results are consistent with a low-potency block of mouse muscle nAChRs; direct evidence for this is illustrated in Figure 12.