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αM-MIIIJ blocks mammalian muscle nAChRs with low potencies. Oocytes expressing nAChRs from human (A) and mouse (B) were voltage-clamped and exposed to αM-MIIIJ as described in Methods. Concentration–response curves for the block by αM-MIIIJ of IACh in oocytes expressing αβδγ (open circles) or αβδε (closed circles) subunits. Solid lines represent best-fit curves to the Langmuir isotherm (see Table 2 for IC50s).
