Table 3.
Peptides of fish-hunting Conus that block nAChRs.1. Cysteine are in bold
| Peptide 2 | Sequence 3 | Reference |
|---|---|---|
| α(3/5) | ||
| α-GI | ECCNPACGRHYSC# | Gray 1981 [37] |
| α-GIA | ECCNPACGRHYSCGK# | Gray 1981 [37] |
| α-GIB | ECCNPACGRHYSCKG# | McIntosh 2002 [40] |
| α-GII | ECCHPACGKHFSC# | Gray 1981 [37] |
| α-MI | GRCCHPACGKNYSC# | McIntosh 1982 [8] |
| α-MIA | DGRCCHPACAKHFNC# | McIntosh 2002 [40] |
| α-MIB | NGRCCHPACGKNYSC# | McIntosh 2002 [40] |
| α-MIC | CCHPACGKNYSC# | Kapono 2013 [39] |
| α-SI | ICCNPACGPKYSC# | Zafaralla 1988 [41] |
| α-SIA | YCCHPACGKNFDC# | Myers 1991 [42] |
| α-SII | GCCCNPACGPNYGCGTSCS | Ramilo 1992 [43] |
| α-Ac1.1a | NGRCCHPACGKHFNC# | Liu 2007 [44] |
| α-Ac1.1b | NGRCCHPACGKHFSC# | Liu 2007 [44] |
| α-CnIA | GRCCHPACGKYYSC# | Favreau 1999 [45] |
| α-CnIB | CCHPACGKYYSC# | Favreau 1999 [45] |
| α(4/7) | ||
| α-EI | RDOCCYHPTCNMSNPQIC# | Martinez 1995 [22] |
| α-MII† | GCCSNPVCHLEHSNLC# | Cartier 1996 [9] |
| α-GIC† | GCCSHPACAGNNQHIC# | McIntosh 2002 [40] |
| α-GID† | IRDγCCSNPACRVNNOHVC | Nicke 2003 [46] |
| α-PIA† | RDPCCSNPVCTVHNPQIC# | Dowell 2003 [47] |
| α-PeIA† | GCCSHPACSVNHPELC# | McIntosh 2005 [48] |
| α(4/4) | ||
| α-BuIA† | GCCSTPPCAVLYC# | Azam 2005 [49] |
| α-PIB | ZSOGCCWNPACVKNRC# | Lopez-Vera 2007 [50] |
| α-EIIA | ZTOGCCWNPACVKNRC# | Quinton 2013 [51] |
| αALong | ||
| αA-PIVA | GCCGSYONAACHOCSCKDROSYCGQ# | Hopkins 1995 [52] |
| αA-EIVA | GCCGPYONAACHOCGCKVGROOYCDROSGG# | Jacobsen 1997 [33] |
| αA-EIVB | GCCGKYONAACHOCGCTVGROOYCDROSGG# | Jacobsen 1997 [33] |
| αAShort | ||
| αA-OIVA | CCGVONAACHOCVCKNTC# | Teichert 2004 [53] |
| αA-OIVB | CCGVONAACPOCVCNKTCG# | Teichert 2005b [54] |
| αA-PeIVA | CCGVONAACHOCVCTGKC | Teichert 2006 [55] |
| αS | ||
| αS-RVIIA | KCNFDKCKGTGVYNCGγSCSCγGLHSCRCTY | |
| NIGSMKSGCACICTYY | Teichert 2005a [54] | |
| αS-GVIIIB† | SGSTCTCFTSTNCQGSCECLSPPGCYCSNN | |
| GIRQRGCSCTCPGT# | Christensen 2015 [56] | |
| αC | ||
| αC-PrXA | TYGIYDAKPOFSCAGLRGGCVLPONLROKFKE# | Jimenez 2007 [29] |
| αM | ||
| ψ-PIIIE | HOOCCLYGKCRRYOGCSSASCCQR# | Shon 1997 [20] |
| ψ-PIIIF | GOOCCLYGSCROFOGCYNALCCRK# | Van Wagoner 2003 [57] |
| ψ-Pr3e | AARCCTYHGSCLKEKCRRKYCC# | Lluisma 2008 [18] |
| αM-MIIIJ | ZKCCSGGSCPLYFRDRLICPCC | This report |
1 All peptides listed block muscle nAChRs except for the following seven that are tagged with a dagger symbol (†): α-MII, α-GIC, α-GID, α-PIA, α-PeIA, α-BuIA, and αS-GVIIIB, which preferentially block neuronal nAChRs over muscle nAChRs for exogenously expressed mammalian receptors (e.g., α6β3β2 and α3β2 for α-MII; α3β2 for α-GIC, and α6β3β2 for α-PIA). 2 First letter following the hyphen indicates Conus species, as follows: Ac, achatinus; E, ermineus; G, geographus; M, magus; O, obscurus; P, purpurascens; Pe, pergrandis; Pr, parius; R, radiatus; and S, striatus. # indicates C-terminal amidation; O, hydroxyproline; Z, pyroglutamate; γ, gamma-carboxyglutamate.