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. 2020 Mar 21;12(3):346. doi: 10.3390/v12030346

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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A proposed model describing the role of TRIM21 in the regulation of HBV DNA Pol and HBV DNA replication. HBV-encoded DNA Pol forms a complex with pgRNA and is packaged into a new viral particle by core protein. Some particles reenter into the nucleus and others are enveloped and released from cells for reinfection. Thus, HBV DNA Pol is necessary for HBV replication. Here, we show that TRIM21 mainly promotes the ubiquitination and degradation of HBV DNA Pol, which reduces HBV DNA replication.