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. 2019 Dec 25;8(1):6. doi: 10.3390/healthcare8010006

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(a) Log-transformed blood glucose (log-BG) time series and latent mean log-BG curves estimated over effect and washout sub-periods. Gray line = time series of observed values; horizontal black line = empirical average log-BG value of 4.324; black lines = estimated latent mean log-BG curves; salmon/teal shaded regions = sleep-deprivation/baseline effect sub-period; vertical lines separate study days that start and end at 06:00. (b) Log-transformed blood glucose (log-BG) pancit plot and latent mean log-BG curves estimated over effect and washout sub-periods. Salmon/teal thin lines = time series of observed values for distinct periods under sleep-deprivation/baseline; salmon/teal thick lines = estimated latent mean log-BG under sleep-deprivation/baseline; horizontal black line = empirical average log-BG value of 4.324; vertical lines separate period days.

(a) Log-transformed blood glucose (log-BG) time series and latent mean log-BG curves estimated over effect and washout sub-periods. Gray line = time series of observed values; horizontal black line = empirical average log-BG value of 4.324; black lines = estimated latent mean log-BG curves; salmon/teal shaded regions = sleep-deprivation/baseline effect sub-period; vertical lines separate study days that start and end at 06:00. (b) Log-transformed blood glucose (log-BG) pancit plot and latent mean log-BG curves estimated over effect and washout sub-periods. Salmon/teal thin lines = time series of observed values for distinct periods under sleep-deprivation/baseline; salmon/teal thick lines = estimated latent mean log-BG under sleep-deprivation/baseline; horizontal black line = empirical average log-BG value of 4.324; vertical lines separate period days.