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. 2020 Mar 13;12(3):264. doi: 10.3390/pharmaceutics12030264

Table 3.

Advantages and disadvantages of liposomes as an oral delivery system.

Advantages Disadvantages
Biocompatibility Physical instability in liquid state
Versatility for drug encapsulation Lysolipid formation by chemical degradation
Flexibility of membrane components Drug leakage
Capability of surface modification Disruption in the stomach
Proposed enhanced permeation Low permeability of intact liposome in the GI tract
Modifiable pharmacokinetic behavior Difficulty in mass production and quality control