Table 5.

Pharmacokinetic parameters of cyclosporine A in rats from different studies.

Researchers	Formulations	Mean Diameter	Dose	AUC0–∞ (µg·h/mL)	Cmax (µg/L)
Shah et al., 2006	drug suspension	-	10 mg/kg	0.2253	0.09
	EPC/CreEL-proLip	10.34 µm	10 mg/kg	2.155	0.3
Guan et al., 2011	Microemulsion	-	15 mg/kg	65.41 ± 29.55	2.57 ± 0.20
	SPC/SDC Lip	85.6 nm	15 mg/kg	73.90 ± 6.63	2.65 ± 0.70
	SPC/CH Lip	98.1 nm	15 mg/kg	60.49 ± 10.79	2.67 ± 0.69
Chen et al., 2013	EPC/CH Lip	165.25 nm	10 mg/kg	9.18 ± 1.06 *	1.14 ± 0.23
	PF127-Lip	172.82 nm	10 mg/kg	11.59 ± 0.70 *	1.37 ± 0.15
	CS-Lip	207.81 nm	10 mg/kg	6.30 ± 0.97 *	0.79 ± 0.10
Deng et al., 2015	drug suspension	-	15 mg/kg	31.14 ± 1.30	1.10 ± 0.14
	Microemulsion	-	15 mg/kg	69.34 ± 7.93	3.40 ± 0.24
	SPC/CH Lip	58.94 nm	15 mg/kg	53.29 ± 4.59	2.85 ± 0.16
	OACS-Lip	69.12 nm	15 mg/kg	100.98 ± 13.08	4.14 ± 0.26

Lip: liposomes; CreEL: Cremophor EL; * AUC_0–12h.