Figure 5.

(A) Uptake of 0.1 μM [³H]para-aminohippuric acid (PAH) was measured in HEK293-mock and –OAT1 cells in the presence and absence of 20 μM probenecid for 5 min. (B) Uptake of 0.1 μM [³H]Estrone-3-sulfate (ES) was measured in HEK293-mock and –OAT3 cells in the presence and absence of 20 μM probenecid. Uptake of (C) DWP16001, (D) dapagliflozin, and (E) ipragliflozin (2 μM each) into HEK293-mock and HEK293 cells expressing OAT1 and OAT3 was measured for 5 min. Each data point represents the mean±standard deviation of triplicate experiments. *: p < 0.05, compared with mock cells; +: p < 0.05, compared with control group.