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. 2020 Mar 15;12(3):268. doi: 10.3390/pharmaceutics12030268

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A) Uptake of 10 μM [¹⁴C]methyl-a-D-glucopyranoside (AMG) was measured in CHO- sodium-glucose cotransporter 1 (SGLT1) cells with a various incubation time (0.5–3 h). (B) Inhibitory effect of dapagliflozin and ipragliflozin (1, 10 μM) on the uptake of 10 μM [¹⁴C]AMG in CHO-mock and -SGLT1 cells was measured for 2 h. Concentration dependent inhibition of DWP16001 (C), dapagliflozin (D), and ipragliflozin (E) on the SGLT1-mediated uptake of [¹⁴C]AMG. SGLT1-mediated uptake of [¹⁴C]AMG was calculated by subtracting the uptake of 10 μM [¹⁴C]AMG for 2 h in CHO-mock cells from that in CHO-SGLT1 cells in a concentration range of 1–50,000 nM of DWP16001, dapagliflozin, and ipragliflozin. Each data point represents the mean ± standard deviation of three independent experiments. *: p < 0.05, compared with control group.