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Protein binding of DWP16001, dapagliflozin, and ipragliflozin in mouse plasma and kidney homogenates.
| Compounds | logP a | Protein Binding (% Bound) b | |
|---|---|---|---|
| Plasma | Kidney | ||
| DWP16001 | 2.65 | 98.50 ± 0.20 | 97.24 ± 0.08 |
| Dapagliflozin | 2.27 | 94.19 ± 1.07 | 95.83 ± 0.68 |
| Ipragliflozin | 2.56 | 96.58 ± 0.75 | 96.50 ± 1.01 |
a logP values were obtained from the partition coefficient of n-octanol/water; b Data expressed as mean ± SD of triplicate experiments.
