Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Inhibition potential of DWP16001, dapagliflozin, and ipragliflozin on SGLT1 and SGLT2 activities.
| IC50 (nM) | Selectivity | ||
|---|---|---|---|
| SGLT1 | SGLT2 | (IC50 Ratio of SGLT1/SGLT2) | |
| DWP16001 | 549.3 ± 139.6 | 0.8 ± 0.3 | 667 |
| Ipragliflozin | 2328.7 ± 377.6 | 8.9 ± 1.7 | 261 |
| Dapagliflozin | 803.0 ± 96.8 | 1.6 ± 0.3 | 493 |
Data were expressed as mean ± SD from triplicate measurement.
