Table 4.

Observed and modelled drug exposure pharmacokinetic parameters for 75 mg immediate release tablets of dipyridamole.

PK Parameter	Ricevuti et al. ± SD	PBPK Using Experimental Biphasic InForm PRC Value ± SD (% PE)	PBPK Using Experimental D-P PRC Value ± SD (% PE)	PBPK Using Default Simulator Precipitation Values ± SD (% PE)	PBPK with no Precipitation ± SD (% PE)
AUC (mg/L h)	4.13 ± 0.52	4.12 ± 1.49 (0.24%)	3.58 ± 1.32 (13.32%)	2.81 ± 1.13 (31.96%)	5.28 ± 1.98 (27.85%)
Cmax (mg/L)	0.93 ± 0.13	0.83 ± 0.21 (10.75%)	0.71 ± 0.18 (23.66%)	0.49 ± 0.15 (47.31%)	1.14 ± 0.29 (22.58%)