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ExPASy predictions for PSEN1 Glu184Gly, compared to normal PSEN1 and Glu184Asp structure: (a). in terms of bulkiness; (b). in terms of polarity; (c). in terms of Kyte & Doolittle hydrophobicity index. Scores of bulkiness and polarity have been dropped significantly due to the mutation, while the hydrophobicity scores have been increased because of the mutation. “a.a. numbers” mean amino acid numbers.
