Figure 1.

(A) The scheme for synthesis of dual responsive nanogels via semi-interpenetration method. The N-isopropylacrylamide (NIPAm)-based polymer network and interpenetrated polypyrrole (PPY) enabled the nanogels with thermoresponsive property and near-infrared (NIR)-induced photothermal convention, respectively; (Pyrrole∙HCl (Py∙HCI) as the base and ammonium persulfate (APS) as an initiator were introduced for polymerization); the TEM images (B) and hydrodynamic size distribution (C) of PPY/Co-dPG nanogels. Adapted from (Journal of Controlled Release. 2019, 311–312, 147–161). Copyright (2020) with permission from Elsevier Science.