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. 2020 Mar 23;12(3):290. doi: 10.3390/pharmaceutics12030290

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

(A) Schematic illustration of the aqueous imprinting method for protein-loaded thermoresponsive nanogels (with APS as an initiator and sodium dodecyl sulfate (SDS) as an emulsifier). The change in temperature below or above VPTT enabled the removal or rebinding of protein. Republished with permission of Royal Society of Chemistry, from [Soft Matter, 2013, 9, 3840–3850. Edition Number 38, Copyright (2013)]; permission conveyed through Copyright Clearance Center, Inc. (B) By hydrolysis of cholesteryl vinyl ether bond at pH 4.0, the acid-labile cholesteryl-bearing pullulan nanogels (acL-CHP) resulted in swelling-collapse and presented the acid-triggered drug release. Adapted with permission from (Biomacromolecules 2013, 14, 56-63). Copyright (2013) American Chemical Society.