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. 2020 Mar 23;12(3):290. doi: 10.3390/pharmaceutics12030290

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

(A) The synthesis of temperature and pH duel-responsive nanogel, and the drug release mechanism of cisplatin (CDDP)-conjugated nanogel when at circulation and in tumor region. Adapted with permission from (Biomaterials. 2013, 34, 8726–8740). Copyright (2013) American Chemical Society. (B) The in situ polymerization of thermo/redox-sensitive nanogels (with potassium persulfate (KPS) as an initiator and SDS as an emulsifier), and the doxorubicin (DOX)-loaded nanogels exhibited both thermo and redox triggered drug responsive release. Republished with permission of Royal Society of Chemistry, from [Journal of materials chemistry. B, Materials for biology and medicine, 2015, 3, 4221–4230. Edition Number 57, Copyright (2015)]; permission conveyed through Copyright Clearance Center, Inc.