(C)
Antigen | Infection Model | Application of mAbs # | Protective | Non-Protective | Reference |
---|---|---|---|---|---|
Histoplasma capsulatum | |||||
histone 2b-like protein | m., i.n. | i.p./−2 h/100 µg | IgM | [59] | |
Hsp60 | m., i.n. | i.p./−2 h/500 µg | IgG1 **, IgG2a | IgG2b ** | [60] |
70 kDa surface protein | m., i.n. | i.p./−2 h/100–500 µg | IgG1 | [61] | |
chitin | m., i.n. | i.p./−2 h/10 µg | WGA-Fc (IgG2a) | [62] | |
Paracoccidioides brasiliensis | |||||
glycoprotein of 70 kDa (gp70) | m., i.t. | i.v./−3 d, 3 d, 6 d, 9 d, 42 d/100 µg each | combination of two IgG1 | [63] | |
75 kDa secreted phosphatase | m., i.t. | i.v./−3 d/100 µg | IgG, IgM | [64] | |
glycoprotein of 43 kDa (gp43) | m., i.t. | i.p./30 d/1 mg | IgG2b | [65] | |
gp43 | m., i.t. | i.m./14 d, 21 d/DCs expressing the scFv s | scFv | [66] | |
m., i.t. | |||||
Paracoccidioides lutzii | |||||
Heat shock protein 60 | m., i.t. | not sp./−24 h/1 mg | IgG2a, IgG2b | [67] | |
Sporothrix schenckii | |||||
70 kDa glycoprotein | m., i.p. | i.p./−24 h, 3 d, 6 d, 42 d/100 µg | IgG1 | [68] | |
70 kDa glycoprotein | m., i.p. | i.p./3 d, 10 d/100 µg | IgG1 | [69] | |
70 kDa glycoprotein | m., i.p. | not sp./3 d/100 µg | hIgG1 | [70] |