Figure 6.

Class 5—Strategies to reduce damage. C. albicans as an ‘Immunoreactive Pathogen’ in denture stomatitis, with mucosal damage occurring across a spectrum of host responses (black curve). Removal of biofilms from dentures and clearance of palatal colonization reduce immune responses, thereby diminishing host damage. Strategies include antifungal therapies via denture-optimized delivery systems and the use of anti-biofilm agents that inhibit fungal adherence to denture materials (green arrow), all of which would minimize both host and biofilm-mediated damage.