Table 5.
Diagnostic accuracy of mpMRI- and bpMRI-based PI-RADS in detection of PCa and CS-PCa for each radiologist: Area under the Receiver Operating Characteristic (ROC) curve (AUC), selected threshold according to the maximum Youden’s index, sensitivity and specificity at threshold. Numbers in square brackets are 95% confidence interval lower and upper bounds for AUC. DCE = dynamic contrast-enhanced MRI; Pos class = positive class; PCa = prostate cancer; PZ = peripheral zone; CS-PCa = clinically significant prostate cancer (defined as Gleason score > 3 + 3); th = threshold; R1 = reader 1; R2 = reader 2; R3 = reader 3. Please note that for diagnostic accuracy analysis in PZ PCa lesion detection, the total sample consisted of 105 PZ lesions, of which 66 positive to biopsy.
| PI-RADS v2.1 Type | Pos Class | AUC [95% CI] |
Youden Selected th | Sen at th | Specificity at th | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| R1 | R2 | R3 | R1 | R2 | R3 | R1 | R2 | R3 | R1 | R2 | R3 | ||
| with DCE | PCa | 0.84 [0.86–0.9] |
0.85 [0.77–0.91] |
0.82 [0.75–0.89] |
>3 | >3 | >3 | 0.80 | 0.82 | 0.82 | 0.72 | 0.77 | 0.72 |
| with DCE | PCa (PZ) |
0.83 [0.75–0.9] |
0.84 [0.76–0.91] |
0.82 [0.74–0.89] |
>3 | >3 | >3 | 0.82 | 0.82 | 0.82 | 0.72 | 0.77 | 0.72 |
| with DCE | CS-PCa | 0.8 [0.72–0.87] |
0.8 [0.71–0.87] |
0.8 [0.71–0.86] |
>3 | >3 | >4 | 0.92 | 0.9 | 0.54 | 0.51 | 0.53 | 0.87 |
| no DCE | PCa | 0.81 [0.73–0.88] |
0.84 [0.76–0.9] |
0.8 [0.73–0.88] |
>3 | >2 | >3 | 0.55 | 0.88 | 0.61 | 0.9 | 0.69 | 0.85 |
| no DCE | PCa (PZ) |
0.81 [0.72–0.88] |
0.83 [0.75–0.9] |
0.8 [0.72–0.88] |
>3 | >2 | >3 | 0.53 | 0.88 | 0.61 | 0.9 | 0.69 | 0.85 |
| no DCE | CS-PCa | 0.8 [0.72–0.87] |
0.82 [0.73–0.88] |
0.82 [0.74–0.89] |
>3 | >3 | >3 | 0.71 | 0.78 | 0.8 | 0.76 | 0.72 | 0.72 |