Table 4.
Treatments and Prognosis of the Patients With COVID-19 or H1N1
| Variable | Total (N = 148) | COVID-19 (n = 73) | H1N1 (n = 75) | P Value |
|---|---|---|---|---|
| Oxygenation stratification | < .001 | |||
| Pao2/Fio2 > 200 mm Hg | 41 (27.7) | 32 (43.8) | 9 (12.0) | |
| 100 mm Hg < Pao2/Fio2 ≤ 200 mm Hg | 66 (44.6) | 36 (49.3) | 30 (40.0) | |
| Pao2/Fio2 ≤ 100 mm Hg | 41 (27.7) | 5 (6.8) | 36 (48.0) | |
| Initial respiratory support | < .001 | |||
| COT | 54 (38.3) | 49 (67.1) | 5 (7.4) | |
| HFNC | 16 (11.3) | 14 (19.2) | 2 (2.9) | |
| NIV | 29 (20.6) | 5 (6.8) | 24 (35.3) | |
| IMV | 42 (29.8) | 5 (6.8) | 37 (54.4) | |
| Initial respiratory support failure | ||||
| COT failure | 20/54 (37.0) | 20/49 (40.8) | 0/5 (0.0) | .145 |
| HFNC failure | 3/16 (18.8) | 3/14 (21.4) | 0/2 (0.0) | .650 |
| NIV failure | 11/29 (37.9) | 5/5 (100.0) | 6/24 (25.0) | .004 |
| Respiratory support during hospitalization | ||||
| COT | 61 (47.3) | 29 (39.7) | 32 (57.1) | .053 |
| HFNC | 54 (40.6) | 22 (30.1) | 32 (53.3) | .008 |
| NIV | 42 (31.3) | 8 (11.0) | 34 (55.7) | < .001 |
| IMV | 73 (51.4) | 14 (19.2) | 59 (85.5) | < .001 |
| ECMO | 35 (25.2) | 10 (13.7) | 25 (25.2) | .002 |
| Antiviral therapy | ||||
| Interferon-α2b | 42 (29.8) | 42 (62.7) | … | … |
| Ganciclovir | 24 (16.2) | 24 (32.9) | … | … |
| Lopinavir/ritonavir | 61 (47.3) | 61 (83.6) | … | … |
| Oseltamivir | 102 (68.9) | 34 (46.6) | 68 (90.7) | < .001 |
| Chinese traditional medicine | 20 (13.5) | 20 (27.4) | … | … |
| Glucocorticoid | 94 (64.4) | 58 (79.5) | 36 (49.3) | < .001 |
| Initial dosage, mg/d | 80 (40, 80) | 80 (40, 80) | 80 (40, 80) | .770 |
| Duration, d | 8 (5, 11) | 8 (5, 11) | 6 (5, 13) | .502 |
| Immunoglobulin | 65 (43.9) | 43 (58.9) | 22 (29.3) | < .001 |
| Outcome | ||||
| Discharge | 75 (50.7) | 26 (35.6) | 49 (65.3) | .001 |
| Death | 47 (31.8) | 21 (28.8) | 26 (34.7) | .483 |
| In-hospital | 26 (17.6) | 26 (35.6) | … | … |
| Hospital stay, d | 14 (9, 21) | 13 (10, 18) | 16 (9, 30) | .247 |
Data are presented as medians (interquartile ranges) or No. (%). COT = conventional oxygen therapy; ECMO = extracorporeal membrane oxygenation; HFNC = high-flow nasal cannula oxygen therapy; IMV = invasive mechanical ventilation; NIV = noninvasive mechanical ventilation. See Table 1 legend for expansion of other abbreviations.