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letter
. 2020 Apr 10;81(2):318–356. doi: 10.1016/j.jinf.2020.03.046

Fig. 1.

Fig. 1

Identification of integrin-binding motifs in S proteins from SARS-CoV-2/ SARS-CoV and ACE2 protein. (A) RGD/KGD is present in S protein from SARS-CoV-2, SARS-CoV, pangolin coronaviruses, and some bat coronaviruses. RGD/KGD motif is in red box. (B) RGD is in an exposed loop of SARS-CoV-2 S protein. Left: trimer of SARS-CoV-2 S protein (PDB: 6VSB). Right: monomer of SARS-CoV-2 S protein. RGD motif is colored red. (C) KGD is in an exposed loop of SARS-CoV S protein. Left: trimer of SARS-CoV S protein (PDB: 5XLR). Right: monomer of SARS-CoV S protein. KGD motif is colored red. (D) RGD of SARS-CoV-2 S protein locates near the groove of the complex of ACE2 and SARS-CoV-2 RBD (PDB: 6LZG). Red: RGD motif. Grey: ACE2, Green: SARS-CoV-2 RBD. (E) KGD of SARS-CoV S protein locates near the groove of the complex of ACE2 and SARS-CoV RBD (PDB: 2AJF). Red: KGD motif. Grey: ACE2, Green: SARS-CoV RBD. (F) KGD presents in human ACE2. KGD motif is in red box. (G) KGD locates in an exposed loop of ACE2. Left: dimer of full-length human ACE2 in complex with B0AT1. Right: monomer of human ACE2. Upper: open conformation (PDB: 6M1D). Lower: closed conformation (PDB: 6M18). KGD motif is colored red.