Table 2.
Risk Factors for Mortality in 140 Patients With Moderate to Critical Coronavirus Disease 2019–Associated Pneumoniaa
| Risk factor | Unadjusted |
Adjustedb |
||
|---|---|---|---|---|
| HR (95%CI) | P value | HR (95%CI) | P value | |
| Demographic and clinical characteristics | ||||
| Age (≥60 y vs <60 y) | 12.21 (3.74-39.84) | <.001 | ||
| Sex (male vs female) | 2.30 (1.13-4.68) | .02 | ||
| Hypertension (yes vs no) | 1.97 (1.02-3.81) | .04 | 1.19 (0.61-2.33) | .61 |
| Any comorbidity (yes vs no) | 5.26 (2.19-12.64) | <.001 | 2.65 (1.07-6.55) | .04 |
| Hypoxemia indices | ||||
| SpO2 (per 1-U increase) | 0.92 (0.91-0.94) | <.001 | 0.93 (0.91-0.95) | <.001 |
| SpO2 ≤90% (≤90% vs >90%) | 77.06 (10.55-562.76) | <.001 | 47.41 (6.29-357.48) | <.001 |
| Dyspnea (yes vs no) | 2.94 (1.42-6.11) | .004 | 2.60 (1.24-5.43) | .01 |
| Blood biochemistryc | ||||
| WBC count (≥10×109/L vs <10×109/L) | 6.21 (3.04-12.69) | <.001 | 2.56 (1.17-5.63) | .02 |
| Neutrophil count (≥6×109/L vs <6×109/L) | 7.43 (3.17-17.42) | <.001 | 4.29 (1.74-10.58) | .002 |
| Lymphocyte count (<1×109/L vs ≥1×109/L) | 1.81 (0.84-3.92) | .13 | 1.10 (0.50-2.41) | .81 |
| Platelet count (<150×109/L vs ≥150×109/L) | 3.77 (1.79-7.94) | <.001 | 2.23 (1.01-4.92) | .05 |
| CRP (≥27.8 mg/L vs <27.8 mg/L) | 28.80 (3.91-212.30) | .001 | 17.02 (2.25-128.59) | .006 |
| D-dimer (≥0.45 μg/mL vs <0.45 μg/mL) | 5.41 (1.20-24.42) | .03 | 3.07 (0.59-15.98) | .18 |
a
CRP = C-reactive protein; HR = hazard ratio; SpO2 = oxygen saturation; WBC = white blood cell.
b
Adjusted for age and sex.
c
Laboratory data were dichotomized based on conventional clinical cutoff values (WBC count, neutrophil count, lymphocyte count, and platelet count) or on median value (CRP and D-dimer).