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. 2020 Feb 20;6(1):7. doi: 10.3390/ncrna6010007

Figure 2.

Figure 2

Snc886-3p is downregulated in tumor vs normal prostate tissue and cell lines. (A) Expression of snc886-3p in paired normal and tumor tissues from patient prostatectomies. Expression of snc886-3p in tumor relative to normal matched prostate tissue was determined by qRT-PCR (ΔΔCt) using RNAU6 as normalizer. Two-tailed paired T-test was performed. (B) Expression of snc886-3p in prostate cell lines. Expression of snc886-3p relative to normal prostate cell line PrEc, determined by qRT-PCR (ΔΔCt) using RNAU6 as normalizer. The order of the cell lines is only based on the expression of snc886-3p (C) Expression of snc886-3p in transcriptomic analysis of small non-coding RNAs from different prostate normal (GEO id: GSE26970) and tumor (SRA id: SRP109305 and GEO id: GSE66035) cell lines. For a better comparison of the different cell lines considering the differences in the depth sequencing among experiments, ranking number of appearances of snc886-3p is shown. (D) Correlation between nc886 and snc886-3p expression and average TSS200nt methylation on prostate cell lines (GSE68379: PrEc, RWPE-1, DU145, PC3, VCAP and LNCaP). Expression data is the same as in (B). Average values and standard deviation are shown.