Table 2.

Antiviral efficacy of selected cationic amphiphilic drugs, adapted from Salata 2017 [32].

Drug	Antiviral Efficacy
Amiodarone	Filovirus—IC50 0.25–1.38 μg/mL Ebola virus—IC50 5.60 μM HCV—EC50 2.10 μM
Bepridil	Ebola virus—IC50 3.21–5.08 μM
Chloroquine and Hydroxychloroquine	CCHFV—IC50 28.00–43.00 μM Filovirus—EC50 4.70–15.00 μM HCoV-OC43—EC50 0.306 μM KSHV—IC50 3.30–5.10 μM MERS-CoV—EC50 3.00–6.28 μM SARS-CoV—EC50 6.54–8.80 μM Dengue virus type 2—EC50 9.70–12.90 μM KSHV—IC50 1.30 μM
Quinacrine	Dengue virus type 2—EC50 7.09 μM Zika virus—EC50 2.27 μM
Mefloquine	Dengue virus type 2 – EC50 4.36 μM Zika virus—EC50 3.95 μM
Chlorpromazine	CCHFV—IC50 10.80–15.70 μM MERS-CoV—EC50 4.90–9.51 μM SARS-CoV—EC50 12.97 μM
Promethazine	Filovirus—IC50 19.10–19.40 μM
Sertraline	Ebola virus—IC50 1.44–3.13 μM
Trimipramine	Filovirus—IC50 10.90–11.10 μM
Clomiphene	Filovirus—IC50 0.76–11.10 μM HCV—EC50
Tamoxifen	HCV—EC50 0.10 μM HSV—IC50 4.89 μM MERS-CoV—EC50 10.12 μM SARS-CoV—EC50 92.89 μM
Toremifene	Filovirus—IC50 0.03–6.17 μM MERS-CoV—EC50 12.92 μM SARS-CoV—EC50 11.97 μM
Sunitinib	HCV—IC50 0.05 μM
Terconazole	Ebola virus—IC50 7.07–8.26 μM
Triparanol	Ebola virus—IC50 1.92 μM