Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Mar 18;13(3):48. doi: 10.3390/ph13030048

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Hippocampal long-term potentiation (LTP) in young rats is weakened after the administration of lipopolysaccharide (LPS) in early postnatal ontogenesis. (A) The normalized field excitatory postsynaptic potentials (fEPSP) slope after theta-burst stimulation (TBS) in control (ctrl) and experimental animals injected with LPS during the first (1wLPS_y) or third (3wLPS_y) postnatal week. The insert (above) shows the positions of electrodes in the hippocampus. (B) Diagram illustrating the difference in LTP values between control and experimental animals (one-way ANOVA: F_2,48 = 3.30; p < 0.05; the significant difference with the control group: * p < 0.05). (C) Representative examples of paired fEPSP responses before (1) and after (2) TBS in control and experimental animals. (D) The paired-pulse ratio (PPR) of the fEPSP amplitudes before and after the induction protocol did not change in either control or experimental rats. Repeated measures ANOVA: F_2,49 = 2.53; p = 0.09 (control, n = 14; 1wLPS_y, n = 18; 3wLPS_y, n = 20).