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. 2020 Mar 18;13(3):48. doi: 10.3390/ph13030048

Figure 4.

Figure 4

The NMDA receptor (NMDAR)-dependent mechanism of LTP induction is disrupted in the CA1 hippocampus of juvenile animals treated with LPS during the third postnatal week. (A–C) The normalized fEPSP slope in the control and experimental groups in the presence of the NMDAR blocker Dizocilpine (MK-801) (10 μM) before and after TBS. (D–F) The relative fEPSP slope in the control and experimental groups in the presence of ifenprodil (If, 3 μM), a selective GluN2B-containing NMDAR antagonist, before and after TBS. (G–H) Diagrams illustrating the magnitude of plasticity in the control and experimental groups in the presence of MK-801 or ifenprodil. Two-way ANOVA following Tukey post hoc tests were used. * p < 0.05.