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. 2020 Mar 18;13(3):48. doi: 10.3390/ph13030048

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The effect of ifenprodil on eEPSCs in CA1 pyramidal neurons. (A) Representative examples of evoked NMDAR-mediated EPSCs recorded at +40 mV in the presence of bicuculline (10 μM), picrotoxin (50 μM), and CNQX (20 μM) in the control and 3wLPS_y groups. (B) The same traces as in (A) normalized by amplitude. Note that ifenprodil decreases tau decay. (C,D) The effect of ifenprodil on amplitude and area under the curve of NMDAR-mediated eEPSC. Dot points represent data from individual cells. Error bars indicate SE.