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. 2020 Mar 18;13(3):48. doi: 10.3390/ph13030048

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Metabotropic glutamate receptor (mGluR)-dependent form of LTP presents in the hippocampal CA1 area of juvenile rats administered with LPS during the third postnatal week. Diagrams showing the normalized slope of fEPSP in the control (A) and experimental (B) groups. Note that FTIDC (4-[1-(2-fluoropyridin-3-yl)-5-methyltriazol-4-yl]-N-methylN-propan-2-yl-3,6dihydro-2H-pyridine-1-carboxamide) (5 μM) affected LTP only in the 3wLPS_y group. (C) Diagram illustrating the effect of FTIDS on LTP values in different groups of rats, respectively * p < 0.05 (t-test).