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HIV-1 protease inhibitor interaction. (A) Saquinavir interacts with the HIV-1 protease backbone residue Asp29 and Asp30. (B) Asparagine moiety in (A) was replaced by 3(R)-tetrahydrofuranylglycine (in pink) to obtain Amprenavir. (C) A cyclic sulfone group, in which the oxygen can accept H bonds from both Asp29 and Asp30 and retain crucial backbone interactions. (D) Darunavir backbone interaction with the HIV-1 protease (PDB code: 2F81).
