Table 3.
Specificity and potency (in µM) of SC compounds against HIV-1J R-CSF, HIV-1 B41, HIV-1 HxBc2 Env, and HIV-1 AMLV pseudotyped HIV-1 using a single-round infection assay.
| Compound | IC50 JR-CSF | IC50 B41 | IC50 HxBc2 | IC50 AMLV |
|---|---|---|---|---|
| SC11 | 0.0008 ± 0.0001 | 0.002 ± 0.0002 | 0.001 ± 0.0001 | N.A. |
| SC12 | 0.008 ± 0.002 | 0.006 ± 0.003 | 0.080 ± 0.020 | N.A. |
| SC15 | 0.003 ± 0.001 | 0.007 ± 0.001 | 0.009 ± 0.001 | N.A. |
| SC28 | 0.096 ± 0.019 | 0.085 ± 0.03 | 0.069 ± 0.014 | N.A. |
| SC45 | 0.224 ± 0.017 | 0.350 ± 0.030 | 0.380 ± 0.030 | N.A. |
N.A. = not active; N.D. = not determined.