Altintas 2000.
| Methods | Prospective double‐blinded randomized controlled trial | |
| Participants | 70 patients aged 17 to 60 years, American Society of Anesthesiologists (ASA) class1 and class 2, who were to undergo plastic surgery | |
| Interventions | 10% lidocaine to inflate the endotracheal tube (ETT) cuff Saline to inflate the ETT cuff | |
| Outcomes | Sore throat Severity of sore throat (visual analogue scale of intensity of sore throat: 0 to 100 mm) Bucking on extubation Plasma lidocaine concentrations | |
| Notes | Topical lidocaine therapy Muscle relaxants used |
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| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Unclear risk | The information on sequence generation is not described. Insufficient information about the sequence generation process to permit judgement of 'Yes' or 'No'. |
| Allocation concealment (selection bias) | Unclear risk | The information on allocation is not described. Insufficient information about the sequence generation process to permit judgement of 'Yes' or 'No'. |
| Blinding (performance bias and detection bias) All outcomes | Low risk | Quote: "Patients were asked about the presence of sore throat by the same anaesthesiologist". The "anaesthesiologist" means "anaesthesiologist who was unaware of the nature of the fluid in the cuff". The patient was anaesthetized and therefore blinded to the intervention. There is no description about double‐blinding. |
| Incomplete outcome data (attrition bias) All outcomes | Unclear risk | The information on incomplete outcome reporting is not described. Insufficient information about the incomplete outcome data. |
| Selective reporting (reporting bias) | Unclear risk | There is no information about selective reporting. |
| Other bias | Unclear risk | There is no apparent description of other bias. |