Table 15.1.
Delivery system, composition, antigen, and immune response
| Delivery system | Composition | Antigen | Immune response | Reference |
|---|---|---|---|---|
| Liposome | DPPC, Chol, DP | Protein/MPL | Systemic IgG and IgA response | [50] |
| DPPC, Chol, DP | Streptococcus mutans protein | Systemic and mucosal antibody responses | [51] | |
| Octyl-beta-D-glucopyranoside | Influenza virus glycoprotein | Local IgA response | [52] | |
| PC, Chol, DCP | Subunit influenza antigen | Systemic IgG and IgA response | [53] | |
| Glycol chitosan coated liposomes | Subunit DNA vaccine | Humoral, cellular, and mucosal immunity | [54] | |
| Particulate system | PLGA | Bovine para influenza virus type-3 | Systemic IgG responses | [55] |
| PLGA | Inactivated PRRS virus | Systemic IgG and MHC-I and MHC-II mediated responses | [56] | |
| Calcium phosphate | Influenza A virus | Producing CD4+ and CD8+ effector T cells | [57] | |
| Chitosan | Tumor pGRP DNA | Systemic IgG responses | [58] | |
| PLGA-coated gelatin | Tetanus toxoid antigen | Humoral, cellular, and mucosal immunity | [59] | |
| PLGA | Hepatitis B antigen | Humoral, cellular, and mucosal immunity | 60., 61. | |
| Chitosan-tripolyphosphate | Influenza virus | Humoral, cellular, and mucosal immunity | [62] | |
| ISCOM | Quil A | Outer-membrane protein of Chlamydia trachomatis | Genital Th1 responses | [63] |
| Quil A | Influenza virus glycoprotein | Systemic IgG, IgA, and CTL responses | [64] | |
| Quil A | Membrane antigens of Mycoplasma mycoides subs. mycoides | Systemic and mucosal antibody responses | [65] | |
| Quil A | Envelope proteins of respiratory syncytial virus (RSV) | IgA antibody and CTL responses | [66] | |
| Virus-like particle | Norwalk virus-like particles (NV VLPs antigen) | Norovirus | Systemic IgG1, IgG2, and IgA responses | [67] |
| 1918 influenza A virus-like particle | Glycoprotein of influenza virus | Systemic IgG responses | [68] | |
| Adjuvanted Norwalk virus-like particle | Noro virus | Systemic and mucosal antibody responses | [69] | |
| Simian immunodeficiency virus (SIV) virus-like particles | SIV virus | Specific serum IgG2 or Th1-oriented immune response | [70] | |
| Emulsion | Influenza virus | W805EC (O/W emulsion) | Humoral and cellular immunity | [71] |
| Ovalbumin | O/W nanoemulsion | Cellular immunity and other specific responses | [72] | |
| HIV gp120 | O/W nanoemulsion | Th1-polarized cellular immune response | [73] | |
| Hepatitis B | Nanoemulsion | Th1-associated cellular immunity | [74] | |
| Bioadhesive delivery system | Influenza (H1N1) | Esterified hyaluronic acid microsphere | Serum IgG responses | [75] |
| HIV rpg160 | Emulsomes (fat, phospholipid, EDTA) | Selected mucosal IgA and IgG responses | [76] | |
| HIV-1 | Capric acid and hydroxyl propyl methylcellulose | Humoral, cellular, and mucosal immunity | [77] | |
| Tetanus toxoid | Dextran microsphere | IgG and IgA immune responses | [78] |