TABLE 26.5.

Distinguishing Features between Leukemoid Reaction and Chronic Myeloid Leukemia

	Leukemoid Reaction	Chronic Myeloid Leukemia
Eosinophils & basophils	Normal count and morphology	Often elevated; may show mixed granulation
Neutrophil morphology	Toxic granulation and Döhle bodies often	May see pseudo-Pelger-Huët forms
Platelet count	Normal	Elevated early; decreased late
Platelet morphology	Normal	Possible giant, hypogranular, and/or bizarre forms
Hemoglobin	Normal	Often anemic
LAP score	Elevated	Decreased
Genetics	Normal	Positive for t(9;22); BCR-ABL

LAP, Leukocyte alkaline phosphatase.