TABLE 26.7.

Reactive Morphologic Changes in Neutrophils

Reactive Change	Appearance	Associated with
Toxic granulation	Dark, blue-black cytoplasmic granules	Inflammation, infection, G-CSF
Döhle bodies	Intracytoplasmic pale blue round or elongated bodies between 1 and 5 μm in diameter, usually adjacent to cellular membranes.	Infection, G-CSF, pregnancy, burns
Cytoplasmic vacuoles	Small to large circular clear areas in cytoplasm, rarely may contain organism	Bacterial infection, autophagocytosis secondary to drug ingestion, acute alcoholism, or excess storage of sample before making blood film

G-CSF, Granulocyte colony-stimulating factor.