Table 4.
Licensed viral vaccines using cell substrates
| Vaccine name | Manufacturer | Trade name | Cell line for production | Virus | Virus type | Virus family |
|---|---|---|---|---|---|---|
| Hepatitis A virus vaccine, inactivated | GlaxoSmithKline Biologicals | Havrix® | MRC-5 | Hepatitis A virus | (+) ssRNA | Picornaviridae |
| Hepatitis A virus vaccine, inactivated | Merck & Co., Inc. | VAQTA® | MRC-5 | Hepatitis A virus | (+) ssRNA | Picornaviridae |
| Japanese encephalitis virus vaccine, inactivated | Intercell Biomedical | IXIARO® | Vero | Japanese encephalitis virus | (+) ssRNA | Flaviviridae |
| Measles virus vaccine, live, attenuated | Merck & Co., Inc. | ATTENUVAX® | Chick embryo cell | Measles virus | (−) ssRNA | Paramyxoviridae |
| Measles, mumps, and rubella virus vaccine, live, attenuated | Merck & Co., Inc. | M-M-R II® | Chick embryo cell | Measles virus | (−) ssRNA | Paramyxoviridae |
| Chick embryo cell | Mumps virus | (−) ssRNA | Paramyxoviridae | |||
| WI-38 | Rubella virus | (+) ssRNA | Togaviridae | |||
| Measles, mumps, rubella, and varicella virus vaccine, live, attenuated | Merck & Co., Inc. | ProQuad® | Chick embryo cell | Measles virus | (−) ssRNA | Paramyxoviridae |
| Chick embryo cell | Mumps virus | (−) ssRNA | Paramyxoviridae | |||
| WI-38 | Rubella virus | (+) ssRNA | Togaviridae | |||
| MRC-5 | Varicella virus | dsDNA | Herpesviridae | |||
| Poliovirus vaccine, inactivated | Sanofi Pasteur SA | IPOL® | Vero | Poliovirus | (+) ssRNA | Picornaviridae |
| Rabies virus vaccine, inactivated | Sanofi Pasteur SA | Imovax® | MRC-5 | Rabies virus | (−) ssRNA | Rhabdoviridae |
| Smallpox (vaccinia) vaccine, live | Acambis Inc. | ACAM2000® | Vero | Vaccinia virus | dsDNA | Poxviridae |
| Varicella virus vaccine, live, attenuated | Merck & Co., Inc. | Varivax® | MRC-5 | Varicella virus | dsDNA | Herpesviridae |
| Varicella-zoster virus vaccine, live, attenuated | Merck & Co., Inc. | Zostavax® | MRC-5 | Varicella-zoster virus | dsDNA | Herpesviridae |
ds, double stranded; (−) ss, negative single stranded; (+) ss, positive single stranded.