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Comparison of Polyclonal and Monoclonal Antibody Therapy
| Polyclonal Antibodies | Monoclonal Antibodies | |
|---|---|---|
| Advantages | Polyvalent specificity Multiple isotypes with different effector functions |
High specific activity Standardized potency Unlimited availability Minimal biohazard potential |
| Disadvantages | Low specific activity Broad variation in potency Limited availability Biohazard risk of human blood products |
Monovalent specificity Single isotype Potential to select for escape mutants |
