Table 58-13.
Chemotherapy Protocols for Feline Alimentary Lymphoblastic Lymphoma
| Drugs | Response Rate | Median Response Duration (Months) | Median Survival Time (Months) | Reference |
|---|---|---|---|---|
| CHOP | 18% CR | n/a | 2.7 mo | 48 |
| COP | 75% CR | 8 mo | 9 mo | 49 |
| COP | 32% CR | 7 mo if CR | n/a | 18 |
| COP or COP then doxorubicin | n/a | 3 mo if COP; 9 mo if COP then doxorubicin | n/a | 50 |
| CVM | 52% | 4 mo | n/a | 51 |
| CVM-L | 62% CR; 20% PR | 7 mo if CR | 52 | |
| Doxorubicin | 42% | Median 2 mo | 53 | |
| Doxorubicin | 22% | n/a | n/a | 54 |
| CHOP-L-M | 47% CR; 33% PR | 22 mo if CR; 4 mo if PR | 22 mo if CR; 4 mo if PR | 55 |
| CHOP-L-M | n/a | 5 mo | 10 mo | 56 |
| CHOP-L-M | 74% CR; 14% PR | 9 mo if CR | 10 mo if CR | 57 |
C, Cyclophosphamide; CR, complete response; H, hydroxydaunorubicin, doxorubicin; L, l-asparaginase; M, methotrexate; n/a, no data available; O, vincristine; P prednisone or prednisolone; PR, partial response; V, vincristine.
Adapted from Gieger T: Alimentary lymphoma in cats and dogs. Vet Clin North Am Small Anim Pract 41:419–432, 2011, with permission.