Table 132-2.

Blood Component Transfusion^*

Product	Indication	Crossmatch	Dose	Expected Rise
PRBCs Leukocyte-reduced PRBCs Irradiated PRBCs Washed PRBCs	Improving blood oxygen-carrying capacity and restoring blood volume Chronic PRBC transfusions Immune-compromised patients Persistent allergic reactions	Complete	10–15 ml/kg	Hemoglobin concentration increases by 2–3 g/dl†
Platelets (whole blood derived)	Thrombocytopenia	ABO	1 unit/10 kg; 4–6 units for adults‡	Platelet count increases by 25–50 × 103/mm3
Platelets (apheresis)	Chronic platelet transfusions	ABO	10 ml/kg; 1 unit for adults§
FFP	Acquired coagulopathy, reversal of warfarin, clotting factor (II, X, XI and XIII) deficiency, TTP and HUS	ABO	10–25 ml/kg	Each coagulation factor increases by 10%–20%¶
Cryoprecipitate	Rich in fibrinogen, von Willebrand's factor, and factor VIII	ABO	1–4 units/10 kg; 8–12 units for adults**	Plasma fibrinogen increases by 60–100 mg/dl

Abbreviations: FFP, fresh frozen plasma; HUS, hemolytic-uremic syndrome; PRBC(s), packed red blood cell(s); TTP, thrombotic thrombocytopenic purpura.

^*Modified from Pisciotto P (ed): Pediatric Hemotherapy Data Card. Bethesda, MD: American Association of Blood Banks, 2002.

^†Increments depend on anticoagulant-preservative solution.

^‡Each unit contains 5.5 × 10¹⁰ platelets in 50 ml of plasma.

^§Each unit contains 3.0 × 10¹¹ platelets in 250 ml of plasma.

^¶Different recovery for each factor (depending on circulatory half-lives).

^**Each unit contains approximately 250 mg of fibrinogen.