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Diagram of the absorption of folate and cobalamin.
Folate is absorbed in the proximal SI by means of carrier-mediated diffusion. Dietary cobalamin is initially protected from digestion by R proteins, and is then absorbed in the ileum through receptor-mediated endocytosis bound to intrinsic factor (IF).
(From Ettinger SJ, Feldman EC, editors: Textbook of Veterinary Internal Medicine, ed 7, Philadelphia, 2010, Saunders, p 1528, Figure 270-1A.)
