Table 11-13.
Chemotherapy Protocols for Lymphoma in Ferrets.a
| Protocol I47,52 | |||
|---|---|---|---|
| Week | Day | Agent | Dosage |
| 1 | 1 | Prednisone | 1-2 mg/kg PO q12h and continued throughout therapy |
| 1 | Vincristine | 0.025 mg/kg IV | |
| 3 | Cyclophosphamide | 10 mg/kg PO, SC | |
| 2 | 8 | Vincristine | 0.025 mg/kg IV |
| 3 | 15 | Vincristine | 0.025 mg/kg IV |
| 4 | 22 | Vincristine | 0.025 mg/kg IV |
| 24 | Cyclophosphamide | 10 mg/kg PO, SC | |
| 7 | 46 | Cyclophosphamide | 10 mg/kg PO, SC |
| 9 | 63 | Prednisone | Gradually decrease dose to 0 over the next 4 wk |
| Protocol IIb,52 | ||
|---|---|---|
| Week | Agent | Dosage |
| 1 | Vincristine | 0.025 mg/kg IV |
| L-asparaginase | 400 U/kg IP | |
| Prednisone | 1 mg/kg PO q24h and continued throughout therapy | |
| 2 | Cyclophosphamide | 10 mg/kg SC |
| 3 | Doxorubicin | 1 mg/kg IV |
| 4-6 | As weeks 1-3 above, but discontinue L-asparaginase | — |
| 8 | Vincristine | 0.025 mg/kg IV |
| 10 | Cyclophosphamide | 10 mg/kg SC |
| 12 | Vincristine | 0.025 mg/kg IV |
| 14 | Methotrexate | 0.5 mg/kg IV |
| Protocol III47 | ||
|---|---|---|
| Week | Agent | Dosage |
| 1 | L-asparaginase | 10,000 U/m2 SC |
| Cytoxin | 250 mg/m2 PO, SC (in 50 mL/kg of NaCl SC) | |
| Prednisone | 2 mg/kg PO daily for 7 days, then q48h throughout therapy | |
| 2 | L-asparaginase | 10,000 U/m2 SC |
| Perform CBCc | ||
| 3 | L-asparaginase | 10,000 U/m2 SC |
| Cytosar | 300 mg/m2 SC × 2 days (dilute 100 mg with 1 mL H20) | |
| 4 | Perform CBCc | |
| 5 | Cytoxin | 250 mg/m2 PO, SC (in 50 mL/kg of NaCl SC) |
| 7 | Methotrexate Perform CBCc | 0.8 mg/kg IM |
| 8 | Perform CBCc | |
| 9 | Cytoxin | 250 mg/m2 PO, SC (in 50 mL/kg of NaCl SC) |
| 11 | Cytosar | 300 mg/m2 SC × 2 days (dilute 100 mg with 1 mL H2O) |
| Leukeran | 1 tablet/animal PO or ½ tablet/animal PO × 2 days | |
| 12 | Perform CBCc | |
| 13 | Cytoxin | 250 mg/m2 PO, SC (in 50 mL/kg of NaCl SC) |
| 15 | Procarbazine | 50 mg/m2 PO q24h × 14 days |
| 16 | Perform CBCc | |
| 17 | Perform CBCc | |
| 18 | Cytoxin | 250 mg/m2 PO, SC (in 50 mL/kg of NaCl SC) |
| 20 | Cytosar | 300 mg/m2 SC × 2 days (dilute 100 mg with 1 mL H2O) |
| Leukeran | 1 tablet/animal PO or ½ tablet/animal PO × 2 days | |
| 23 | Cytoxin | 250 mg/m2 PO, SC (in 50 mL/kg of NaCl SC) |
| 26 | Procarbazine | 50 mg/m2 PO q24h × 14 days |
| 27 | Perform CBCc and chemistry panel | If not in remission, continue weeks 20-26 for 3 cycles |
| Protocol IV4 | ||
|---|---|---|
| Week | Agent | Dosage |
| 3 days | L-asparaginase | 400 U/kg SC (premedicate with diphenhydramine) |
| 1 | Vincristine | 0.12 mg/kg IV |
| Prednisone | 1 mg/kg PO q24h continue throughout therapy | |
| Cyclophosphamide | 10 mg/kg PO | |
| 2 | Vincristine | 0.12 mg/kg IV |
| 3 | Vincristine | 0.12 mg/kg IV |
| 4 | Vincristine | 0.12 mg/kg IV |
| Cyclophosphamide | 10 mg/kg PO | |
| 7, 10, 13, etc. | Vincristine | 0.12 mg/kg IV |
| Cyclophosphamide | 10 mg/kg PO | |
| Continue therapy every 3 wk for 1 yr, then decrease to every 4-6 wk | ||
| Rescue treatment | Doxorubicin | 1-2 mg/kg IV (over 20 min) |
a
CBC should be checked weekly during therapy; after therapy is discontinued, continue to monitor CBC and do physical examination at 3-mo intervals.
b
Protocol is continued in sequence biweekly after week 14, making the therapy protocol less intensive.
c
If CBC shows severe myelosuppression, reduce dosage by 25% for all subsequent treatments of the previously used myelosuppressive drug.