Table 2.
Examples of protease patents issued by the US Patent Office during 2008–10
| US patent no | Protease patent title |
|---|---|
| 7,763,430 | Diagnostic assay for anti-von Willebrand Factor cleaving protease (ADAMTS13) antibodies |
| 7,759,103 | Extracellular serine protease |
| 7,750,134 | Nucleic acids encoding microbial SUMO protease homologs |
| 7,745,395 | Proaerolysin containing protease activation sequences and methods of use for treatment of prostate cancer |
| 7,737,263 | Modified Cry35 proteins having altered protease stability |
| 7,718,766 | Fret protease assays for botulinum serotype A/E toxins |
| 7,718,763 | Substrate polyeptides for von Willebrand factor cleaving protease ADAMTS-13 |
| 7,709,621 | Vectors with modified protease-dependent tropism |
| 7,709,608 | Substrates useful for FRET protease assays for botulinum serotype A/E toxins |
| 7,696,309 | Protease resistant mutants of stromal cell derived factor-1 in the repair of tissue damage |
| 7,691,597 | Method for measuring protease activity of transglutaminase and transglutaminase composition |
| 7,678,550 | FRET protease assays for botulinum serotype A/E toxins |
| 7,670,821 | Method for the purification of microbial protease |
| 7,662,860 | 3D-structure model of SARS coronavirus 3CL protease and anti-SARS drugs |
| 7,659,380 | Method of isolation and purification of trypsin from pronase protease and use thereof |
| 7,658,965 | Use of acid stable protease in animal feed |
| 7,638,277 | Transmembrane serine protease overexpressed in ovarian carcinoma and uses thereof |
| 7,635,679 | Protease resistant mutant of human HMGB1 high affinity binding domain Box-A (HMGB1 Box-A) |
| 7,622,558 | Antibodies which are directed against the Marburg I polymorphism of factor VII-activating protease (FSAP), and their preparation and use |
| 7,622,292 | Regulation of human transmembrane serine protease |
| 7,618,801 | Streptomyces protease |
| 7,611,700 | Protease resistant modified interferon alpha polypeptides |
| 7,608,444 | Use of acid stable protease in animal feed |
| 7,601,807 | Protease, DNA encoding the same, and method for manufacturing protease |
| 7,595,183 | Cathepsins L-like cysteine protease derived from northern shrimp (Pandalus eous) |
| 7,588,927 | Composition and methods relating to SENP1-- a sentrin-specific protease |
| 7,569,226 | Alkaline protease from Bacillus sp. (DSM 14392) and washing and cleaning products comprising said alkaline protease |
| 7,563,872 | Protease, a gene therefor and the use thereof |
| 7,563,607 | Acid fungal protease in fermentation of insoluble starch substrates |
| 7,541,156 | Method of identifying antinociceptive compounds using protease activated receptor-2 |
| 7,538,205 | Regulation of human prostasin-like serine protease |
| 7,537,901 | Extracellular serine protease |
| 7,531,317 | Fluorescence polarization assay to detect protease cleavage |
| 7,521,209 | Insertion of furin protease cleavage sites in membrane proteins and uses thereof |
| 7,501,117 | Composition exhibiting a von Willebrand factor (vWF) protease activity comprising a polypeptide chain with the amino acid sequence AAGGILHLELLV |
| 7,494,768 | Mutational profiles in HIV-1 protease and reverse transcriptase correlated with phenotypic drug resistance |
| 7,494,660 | HCV NS3-NS4A protease resistance mutants |
| 7,482,147 | Ubiquitin protease |
| 7,473,821 | Nucleic acids encoding Cry8Bb1 endotoxins engineered to have insect-specific protease recognition sequences |
| 7,473,524 | Mutational profiles in HIV-1 protease correlated with phenotypic drug resistance |
| 7,462,760 | Genes encoding plant protease-resistant pesticidal proteins and method of their use |
| 7,455,992 | Lactobacillus acidophilus nucleic acid sequences encoding protease homologues and uses therefore |
| 7,452,708 | Human PRSS11-like S2 serine protease and uses thereof |
| 7,452,690 | Protease EFC cell surface fusion protein assay |
| 7,449,187 | Alkaline protease from Bacillus gibsonii (DSM 14391) and washing and cleaning products comprising said alkaline protease |
| 7,442,514 | Mutants of the factor VII-activating protease and detection methods using specific antibodies |
| 7,439,240 | Purine-or pyrrolol[2,3-d]pyrimidine-2-carbonitiles for treating diseases associated with cysteine protease activity |
| 7,432,093 | Soluble, functional apoptotic protease-activating factor 1 fragments |
| 7,427,666 | Antibody directed against a ubiquitin-specific protease occurring in the brain |
| 7,425,323 | Treatment and composition for achieving skin anti-aging benefits by corneum protease activation |
| 7,416,855 | Immunoassay methods for detecting interleukin-1 beta converting enzyme like apoptosis protease-3 |
| 7,410,769 | Peptide biosensors for anthrax protease |
| 7,410,765 | System for protease mediated protein expression |
| 7,402,427 | Vectors with modified protease-dependent tropism |
| 7,384,773 | Crystal of HIV protease-cleaved human beta secretase and method for crystallization thereof |
| 7,384,758 | Bioluminescent protease assay with modified aminoluciferin or derivatives thereof |
| 7,374,896 | GFP-SNAP25 fluorescence release assay for botulinum neurotoxin protease activity |
| 7,361,748 | von Willebrand factor (vWF)--cleaving protease |
| 7,355,015 | Matriptase, a serine protease and its applications |
| 7,344,856 | Method of controlling cleavage by OmpT protease |
| 7,339,092 | Plant activation of Cry8Bb1 by insertion of a plant protease-sensitive site |
| 7,332,567 | Fret protease assays for clostridial toxins |
| 7,332,320 | Protease producing an altered immunogenic response and methods of making and using the same |
| 7,329,506 | Apparatuses and methods for determining protease activity |
| 7,323,558 | Nucleic acids encoding dendritic cell transmembrane serine protease |
| 7,320,887 | Alkaline protease variants |
| 7,320,878 | Protease assay for therapeutic drug monitoring |
| 7,314,744 | Hyperthermostable protease gene |
| 7,314,730 | Regulation of human transmembrane serine protease |