Fig. 6.

Protection effect of bismuth on mice exposed to overdosed cisplatin treatment. Survival curve of cisplatin-treated SCID Beige mice with or without treatment of BiZn (Top). Renal histological differentiation (middle) and Renal functions i.e. Blood BUN and creatinine (bottom) between mice that untreated or pretreated with BiZn after days of cisplatin administration.

Adapted from Chan C, Wang R, et al. (2019) A novel synthetic compound, bismuth zinc citrate, could potentially reduce cisplatin-induced toxicity without compromising the anticancer effect through enhanced expression of antioxidant protein. Translational Oncology 12: 788–799.with permission from Elsevier.