TABLE 12-1.

Advantages and Disadvantages of Attenuated Live and Inactivated Vaccines

	Attenuated Live	Inactivated
Advantages	Rapid onset of immunity Sustained immunity after single dose May immunize others in populations Improved breakthrough of maternal antibody interference	Safe, even in immunocompromised and pregnant animals Do not interfere with development of immunity from other vaccines Stable in storage
Disadvantages	Potential for reversion to virulence Virulence in the immunocompromised Contraindicated in pregnancy May cause immune suppression Can interfere with development of immunity if administered within days to 2 weeks of another vaccine Less stable in storage Potential for vaccine contamination	Slow onset of immunity Multiple boosters required Often highly adjuvanted, with greater potential for adverse effects Reduced degree of protection compared with attenuated live vaccines Poor breakthrough of maternal antibody interference