Table 1:
Summary of circuit dysfunctions in Cntnap2 KO mouse model
| 2–3 weeks | 4–8 weeks | > 2 months | |
|---|---|---|---|
| Hippocampus | Reduced density of PV+ INs (Lauber etal. 2018) | No difference in INs density (PV+, SOM+, CR+ (Scott et al. 2019) | Reduced density of PV+ INs (Penagarikano et al. 2011) Reduced immature DCX neurons in ventral hippocampus (Cope et al. 2016) No difference in astroglia (Cope et al. 2016) Decresead perisomatic inhibition (Jungersen et al. 2015) |
| mPFC | No difference in density of PV+ INs, (Lauberet al. 2018; Lazaro et al. 2019) Decreased inhlbitoty & excitatory Input into layer ll/lll (Lazaro et al. 2019) Decreased phase-locking excitatory units to delat and theta rhythm during locomotion (Scott et al. 2019) |
No difference in astroglia (Cope et al. 2016) | |
| Somatosensory cortex | Reduced density of PV+ INs (Penagarikano et al. 2011) Increased expression of CUX1 In deep layers (Penagarikano et al. 2011) Normal expression of Chat (Penagarikano et al. 2011) |
No difference in INs density (PV+, SST+, CR+ (Scott et al. 2019) Reduced density of PV+ and Reelin+ INs and no difference in VIP+ and SST+(Vogt etal. 2017) Increased sEPSC and no difference in sIPSC in layer ll/lll (Scott et al. 2019) Reduced mIPSCand Increased firing rate of PC in layer ll/lll (Antoine et al 2019) Decreased whisker-evoked firing rate for FS units in layer ll/lll and RS units in layer IV (Antoine et al 2019) |
Reduced spine density in layer V (Gdalyahu et al. 2015) Increased expression of CUX1 in deep layers (Penagarikano et al. 2011) Normal expression of Foxp2 (Penagarikano et al. 2011) Asynchronous firign pattern in layer ll/lll (Penagarikanoetal.2011) |
| Striatum | Reduced density of PV+ INs (Penagarikano et al. 2011; Lauber et at 2018) Normal expression of Chat (Penagarikano et al. 2011) |
Reduced density of PV+ INs with no difference in WA+ cells (Lauber et al. 2018) | No difference in astroglia (Cope et al. 2016) |
| Visual cortex | Reduced phasic inhibition and no difference in tonic inhibition (Bridi et al. 2017) | ||
| Other | Neural migration abnormalities (Penagarikano et al. 2011) Increased gray matter myelination (Scott etal. 2019) |
Normal gray matter myelination (Scott etal. 2019) Altered clustering of Kv2.1 in cortical axons (Scott et al. 2019) |
Reduced power (9–12 Hz) during wakefulness (Thomas et al. 2017) Absence of spontaneous seizures (Thomas et al. 2017) Spontaneous seizures in mice older than 6 months (Penagarikano et al. 2011) Neural migration abnormality (Penagarikano et al. 2011) |
FR: firing rate; PC: principal cells