TABLE 8.1.
Acceleration of Routine Vaccine Schedule for Travela
| Vaccine | Earliest Age for First Dose | Minimum Interval Between Doses |
|---|---|---|
| Combined hepatitis A and Bb | 1 yr | 1 wk, 2 wk between second and third doses (booster after 1 yr) |
| Hepatitis A | 1 yr | 6 monthsc |
| DTaP | 6 wk | 4 wk, 6 mo between third and fourth doses |
| IPV | 6 wk | 4 wk |
| OPV | Birth | 4 wk |
| Hib (conjugate) | 6 wk | 4 wk (booster after 12 months of age) |
| Hepatitis B | Birth | 4 wk, 8 wk between second and third doses (third dose should be given ≥16 weeks after first dose) |
| PCV13 | 6 wk | 4 wk, 8 wk between third and fourth doses (after 12 mo of age) |
| Measles | 6 mo followed by MMR at 12 mo and at 4 to 6 yr of age | 4 wk |
| MMR | 12 mo | 4 wk |
| Rotavirusd | 6 wk | 4 wk |
| Varicella | 12 mo | 4 wk if ≥13 yr of age 3 mo if <13 yr of age |
DTaP, diphtheria and tetanus toxoids and acellular pertussis; Hib, Haemophilus influenzae type b; IPV, inactivated poliovirus vaccine; MMR, measles, mumps, rubella; OPV, oral poliovirus vaccine; PCV13, 13-valent pneumococcal conjugate vaccine.
Regular immunization schedule should be reinstituted on return from the endemic area.
Combined hepatitis A and B accelerated schedule is an off-label use for children.
Hepatitis A booster does not need to be given as an accelerated schedule because the seroconversion rate following the first dose is high. The second dose can be given any time after 6 months to induce long-lasting immunity.
For rotavirus vaccine, the maximum age for the first dose is 14 wk and 6 days, and the maximum age for the last dose is 8 months and 0 days.